Unlock Your Body’s Natural Defense
Avmacol Extra Strength – Sulforaphane Production System
Supports Natural Detoxification, Cellular Health & Internal Defense
Detoxification Support
Avmacol® Extra Strength builds on the regular formula by adding beta-glucan to support your body’s natural detoxification process and overall cellular health, working better than sulforaphane alone.
Sulforaphane Generator
This formula features the Sulforaphane Production System®: broccoli seed and sprout extract (glucoraphanin) plus active myrosinase (Myrosimax®), helping your body make sulforaphane to support internal defense.
Works Synergistically
Avmacol® Extra Strength includes beta-glucan and maitake mushroom, known for their immune properties, to work synergistically with our sulforaphane-producing blend.
Backed by Research
Avmacol® has been selected for use in more sulforaphane human clinical trials than any other supplement. Our formula can be trusted by researchers and backed by science.
How Maitake Mushroom Extract Works in Combination with Sulforaphane
The Maitake mushroom extract (containing beta-glucans) works in combination with sulforaphane to support your body’s natural detoxification process better than sulforaphane alone. In addition, the Maitake mushroom extract found in Avmacol® Extra Strength provides the added bonus of immune support by promoting neutrophil function and natural killer cell activity.
The Science Behind Avmacol ® Extra Strength
The combination of sulforaphane and Maitake extract supports the movement (or translocation) from the cytoplasm to the nucleus of NRF2 and increases the levels of certain Phase 2 enzymes. Below are images of a technique called immunofluorescence which illustrate how much protein is being produced in the cell and the location of that protein.
Translocation of NRF2 into the Nucleus Following Exposure to Sulforaphane and Maitake Mushroom Extract
In control cells (left panel), the green staining indicates that NRF2 remains largely in the cytoplasm (arrows) without much protein located in the nucleus, which is counter-stained in blue. When cells are exposed to sulforaphane and Maitake (right panel), NRF2 moves to the nucleus (arrows) where it can bind to DNA to turn on expression of certain Phase 2 enzymes.
Sulforaphane and Maitake Extract Boosts Select Phase 2 Enzyme Production Including NQO1 and HO-1
NQO1 Protein Expression in THLE2 Liver Cells
In control cells (left panel) NQO1 protein expression is indicated by the green staining. When cells are exposed to sulforaphane and Maitake (right panel), the level of NQO1 staining, representing the amount of protein, is increased.
HO-1 Protein Expression in THLE2 Liver Cells
In control cells (left panel) HO-1 protein expression is indicated by the green staining. When cells are exposed to sulforaphane and Maitake (right panel), the level of HO-1 staining, representing the amount of protein, is increased.